PHCCC

• Supplier: Tocris Bioscience
• Catalog: 4535
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 179068-02-1
• Chemical Name: N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
• Formula: C17H14N2O3
• Molecular Weight: 294.31
• Purity: >98 %
• Description: Group I metabotropic glutamate receptor antagonist (IC 50 ~ 3 μ M); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu 4a ; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro . Displays antiParkinsonian effects in rats in vivo .

Product References

Selective activation of group I metabotropic glutamate receptors upregulates - Selective activation of group I metabotropic glutamate receptors upregulates

Mao L, Wang JQ. Synapse. 2001 Jan;39(1):82-94.

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential - Allosteric modulation of group III metabotropic glutamate receptor 4: a potential

Marino MJ, Williams DL Jr, O'Brien JA, Valenti O, McDonald TP, Clements MK, Wang R, DiLella AG, Hess JF, Kinney GG, Conn PJ. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. Epub 2003 Oct 30.