Phenamil

• Supplier: Tocris Bioscience
• Catalog: 1027
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1161-94-0
• Chemical Name: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamidemethanesulfonatesalt
• Formula: C12H12ClN7O.CH3SO3H
• Molecular Weight: 401.83
• Purity: >99 %
• Description: TRPP3 channel inhibitor (IC 50 = 0.14 μ M). Also inhibits epithelial Na + channels (K d = 0.4 nM for a high affinity site on the epithelial Na + channel). Derivative of amiloride (Cat. No. 0890).

Product References

Biochemical identification of two types of phenamil binding sites associated with - Biochemical identification of two types of phenamil binding sites associated with

Barbry P, Chassande O, Duval D, Rousseau B, Frelin C, Lazdunski M. Biochemistry. 1989 May 2;28(9):3744-9.

Inhibition of TRPP3 channel by amiloride and analogs. - Inhibition of TRPP3 channel by amiloride and analogs.

Dai XQ, Ramji A, Liu Y, Li Q, Karpinski E, Chen XZ. Mol Pharmacol. 2007 Dec;72(6):1576-85. Epub 2007 Sep 5.