9-Phenanthrol

Name 9-Phenanthrol
Supplier Tocris Bioscience
Catalog 3379
Prices $59.00
Sizes 50 mg
Function Type Blocker
Cas Number 484-17-3
Chemical Name 9-Hydroxyphenanthrene
Formula C14H10O
Molecular Weight 194.23
Description Selective TRPM4 blocker (IC 50 = 20 μ M in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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Product References

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. - 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, Bois P, Guinamard R. Br J Pharmacol. 2008 Apr;153(8):1697-705.

Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes - Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes

Simard C, Salle L, Rouet R, Guinamard R. Br J Pharmacol. 2012 Apr;165(7):2354-64.