Sodium 4-Phenylbutyrate

• Supplier: Tocris Bioscience
• Catalog: 0969
• Prices: $95.00
• Sizes: 100 mg
• Function Type: Inhibitor
• Cas Number: 1716-12-7
• Chemical Name: 4-Phenylbutyricacid,sodiumsalt
• Formula: C10H11NaO2
• Molecular Weight: 186.18
• Purity: >99 %
• Description: Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ -globin gene and affects hPPAR γ activation.

Product References

Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression - Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression

Appelskog IB, Ammerpohl O, Svechnikova IG, Lui WO, Almqvist PM, Ekstrom TJ. Int J Oncol. 2004 Jun;24(6):1419-25.

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and - Complementary effects of HDAC inhibitor 4-PB on gap junction communication and

Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, Saeger HD, Janssen O, Sipos B, Kloppel G, Kalthoff H. Br J Cancer. 2007 Jan 15;96(1):73-81. Epub 2006 Dec 12.

HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic - HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic

Khan Z, Akhtar M, Ekstrom TJ. Int J Mol Med. 2011 Dec;28(6):977-83.