2-Phenylmelatonin

• Supplier: Tocris Bioscience
• Catalog: 2838
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 151889-03-1
• Chemical Name: N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide
• Formula: C19H20N2O2
• Molecular Weight: 308.38
• Purity: >98 %
• Description: Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC 50 values for G protein activation in MT 1 and MT 2 -transfected cells are 65 and 58 pM respectively.

Product References

2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the - 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the

Spadoni G, Stankov B, Duranti A, Biella G, Lucini V, Salvatori A, Fraschini F. J Med Chem. 1993 Dec 10;36(25):4069-74.

Pharmacological characterization of the human melatonin Mel1a receptor following - Pharmacological characterization of the human melatonin Mel1a receptor following

Nonno R, Lucini V, Pannacci M, Mazzucchelli C, Angeloni D, Fraschini F, Stankov BM. Br J Pharmacol. 1998 Jun;124(3):485-92.

Ligand efficacy and potency at recombinant human MT2 melatonin receptors: - Ligand efficacy and potency at recombinant human MT2 melatonin receptors:

Nonno R, Pannacci M, Lucini V, Angeloni D, Fraschini F, Stankov BM. Br J Pharmacol. 1999 Jul;127(5):1288-94.