PhiKan 083

• Supplier: Tocris Bioscience
• Catalog: 0730
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Cas Number: 880813-36-5
• Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanaminehydrochloride
• Formula: C16H18N2.HCl
• Molecular Weight: 274.79
• Purity: >99 %
• Description: p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Product References

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. - Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.

Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. doi:

Pharmacological reactivation of mutant p53: from protein structure to the cancer - Pharmacological reactivation of mutant p53: from protein structure to the cancer

Wiman KG. Oncogene. 2010 Jul 29;29(30):4245-52.