Philanthotoxin 74

• Supplier: Tocris Bioscience
• Catalog: 4326
• Prices: $95.00, $199.00, $825.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1227301-51-0
• Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamidedihydrochloride
• Formula: C24H42N4O3.2HCl
• Molecular Weight: 507.54
• Purity: >98 %
• Description: AMPA receptor antagonist. Non-selective homomeric GluR3 and GluR1 receptor antagonist (IC 50 values are 263 and 296 nM respectively). Inhibits homomeric GluR3 and GluR1 with a 100-fold greater potency than heteromeric GluR1/2 and GluR2/3 receptors.

Product References

A subtype-selective, use-dependent inhibitor of native AMPA receptors. - A subtype-selective, use-dependent inhibitor of native AMPA receptors.

Nilsen A, England PM. J Am Chem Soc. 2007 Apr 25;129(16):4902-3. Epub 2007 Mar 29.

Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA - Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA

Poulsen MH, Lucas S, Stromgaard K, Kristensen AS. Mol Pharmacol. 2014 Feb;85(2):261-8.