Phorbol 12-myristate 13-acetate

Name Phorbol 12-myristate 13-acetate
Supplier Tocris Bioscience
Catalog 4153
Prices $75.00, $249.00
Sizes 1 mg, 5 mg
Function Type Activator
Cas Number 16561-29-8
Chemical Name (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yltetradecanoate
Formula C36H56O8
Molecular Weight 616.83
Purity >99 %
Description Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a K i value of 2.6 nM as measured by displacement of [ 3 H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.
Supplier Page Shop

Product References

Direct activation of calcium-activated, phospholipid-dependent protein kinase by - Direct activation of calcium-activated, phospholipid-dependent protein kinase by

Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. J Biol Chem. 1982 Jul 10;257(13):7847-51.

A diacylglycerol analogue reduces neuronal calcium currents independently of - A diacylglycerol analogue reduces neuronal calcium currents independently of

Hockberger P, Toselli M, Swandulla D, Lux HD. Nature. 1989 Mar 23;338(6213):340-2.

Structural determinants of phorbol ester binding in synaptosomes: - Structural determinants of phorbol ester binding in synaptosomes:

Murphy TV, Prountzos C, Kotsonis P, Iannazzo L, Majewski H. Eur J Pharmacol. 1999 Sep 17;381(1):77-84.