Phortress

• Supplier: Tocris Bioscience
• Catalog: 1201
• Prices: $219.00, $905.00
• Sizes: 10 mg, 50 mg
• Cas Number: 328087-38-3
• Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamidedihydrochloride
• Formula: C20H23FN4OS.2HCl
• Molecular Weight: 459.41
• Purity: >98 %
• Description: Prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.

Product References

Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive - Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive

Leong CO, Gaskell M, Martin EA, Heydon RT, Farmer PB, Bibby MC, Cooper PA, Double JA, Bradshaw TD, Stevens MF. Br J Cancer. 2003 Feb 10;88(3):470-7.

DNA damage and cell cycle arrest induced by - DNA damage and cell cycle arrest induced by

Trapani V, Patel V, Leong CO, Ciolino HP, Yeh GC, Hose C, Trepel JB, Stevens MF, Sausville EA, Loaiza-Perez AI. Br J Cancer. 2003 Feb 24;88(4):599-605.

The development of the antitumour benzothiazole prodrug, Phortress, as a clinical - The development of the antitumour benzothiazole prodrug, Phortress, as a clinical

Bradshaw TD, Westwell AD. Curr Med Chem. 2004 Apr;11(8):1009-21.

In vitro, in vivo, and in silico analyses of the antitumor activity of - In vitro, in vivo, and in silico analyses of the antitumor activity of

Leong CO, Suggitt M, Swaine DJ, Bibby MC, Stevens MF, Bradshaw TD. Mol Cancer Ther. 2004 Dec;3(12):1565-75.