PHT 427

• Supplier: Tocris Bioscience
• Catalog: 4914
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1191951-57-1
• Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
• Formula: C20H31N3O2S2
• Molecular Weight: 409.61
• Purity: >98 %
• Description: Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (K i values are 2.7 and 5.2 μ M, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro . Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Product References

In vitro and in vivo activity of novel small-molecule inhibitors targeting the - In vitro and in vivo activity of novel small-molecule inhibitors targeting the

Moses SA, Ali MA, Zuohe S, Du-Cuny L, Zhou LL, Lemos R, Ihle N, Skillman AG, Zhang S, Mash EA, Powis G, Meuillet EJ. Cancer Res. 2009 Jun 15;69(12):5073-81.

Molecular pharmacology and antitumor activity of PHT-427, a novel - Molecular pharmacology and antitumor activity of PHT-427, a novel

Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G. Mol Cancer Ther. 2010 Mar;9(3):706-17.