Piclamilast

• Supplier: Tocris Bioscience
• Catalog: 1554
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 144035-83-6
• Chemical Name: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
• Formula: C18H18Cl2N2O3
• Molecular Weight: 381.25
• Purity: >99 %
• Description: Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC 50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB 4 synthesis in human neutrophils (IC 50 = 2 nM).

Product References

Anti-inflammatory and bronchodilator properties of RP 73401, a novel and - Anti-inflammatory and bronchodilator properties of RP 73401, a novel and

Raeburn D, Underwood SL, Lewis SA, Woodman VR, Battram CH, Tomkinson A, Sharma S, Jordan R, Souness JE, Webber SE, et al.. Br J Pharmacol. 1994 Dec;113(4):1423-31.

Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor - Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor

Hatzelmann A, Schudt C. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79.

Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using - Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using

Zhao Y, Zhang HT, O'Donnell JM. J Pharmacol Exp Ther. 2003 May;305(2):565-72.