Picropodophyllotoxin

• Supplier: Tocris Bioscience
• Catalog: 4525
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 477-47-4
• Chemical Name: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Formula: C22H22O8
• Molecular Weight: 414.41
• Purity: >97 %
• Description: Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .

Product References

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and - Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and

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IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces - IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces

Stromberg T, Ekman S, Girnita L, Dimberg LY, Larsson O, Axelson M, Lennartsson J, Hellman U, Carlson K, Osterborg A, Vanderkerken K, Nilsson K, Jernberg-Wiklund H. Blood. 2006 Jan 15;107(2):669-78. Epub 2005 Sep 15.

Inhibition of VEGF secretion and experimental choroidal neovascularization by - Inhibition of VEGF secretion and experimental choroidal neovascularization by

Economou MA, Wu J, Vasilcanu D, Rosengren L, All-Ericsson C, van der Ploeg I, Menu E, Girnita L, Axelson M, Larsson O, Seregard S, Kvanta A. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2620-6.