Pifithrin- α hydrobromide

Name Pifithrin- α hydrobromide
Supplier Tocris Bioscience
Catalog 1128
Prices $149.00, $629.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 63208-82-2
Chemical Name 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanonehydrobromide
Formula C16H18N2OS.HBr
Molecular Weight 367.3
Description Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC 50 = 1.1 μ M). Cyclic analog available (Cat. No. 3843).
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Product References

A chemical inhibitor of p53 that protects mice from the side effects of cancer - A chemical inhibitor of p53 that protects mice from the side effects of cancer

Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV. Science. 1999 Sep 10;285(5434):1733-7.

Suppression of p53: a new approach to overcome side effects of antitumor therapy. - Suppression of p53: a new approach to overcome side effects of antitumor therapy.

Komarova EA, Gudkov AV. Biochemistry (Mosc). 2000 Jan;65(1):41-8.

A synthetic inhibitor of p53 protects neurons against death induced by ischemic - A synthetic inhibitor of p53 protects neurons against death induced by ischemic

Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, Greig NH, Mattson MP. J Neurochem. 2001 Apr;77(1):220-8.

The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon - The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon

Hoagland MS, Hoagland EM, Swanson HI. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10. Epub 2005 Apr 20.

The p53 inhibitor, pifithrin-alpha, suppresses self-renewal of embryonic stem - The p53 inhibitor, pifithrin-alpha, suppresses self-renewal of embryonic stem

Abdelalim EM, Tooyama I. Biochem Biophys Res Commun. 2012 Apr 13;420(3):605-10. doi: