Cyclic Pifithrin- α hydrobromide

• Supplier: Tocris Bioscience
• Catalog: 1267
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 511296-88-1
• Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
• Formula: C16H16N2S.HBr
• Molecular Weight: 349.29
• Purity: >98 %
• Description: Cyclic analog of pifithrin- α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC 50 = 2.01 μ M). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Product References

Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of - Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of

Barchechath SD, Tawatao RI, Corr M, Carson DA, Cottam HB. J Med Chem. 2005 Oct 6;48(20):6409-22.

Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological - Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological

Pietrancosta N, Maina F, Dono R, Moumen A, Garino C, Laras Y, Burlet S, Quelever G, Kraus JL. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule - Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule

Zuco V, Zunino F. Neoplasia. 2008 Jun;10(6):587-96.