Pifithrin- μ

• Supplier: Tocris Bioscience
• Catalog: 3843
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Cas Number: 64984-31-2
• Chemical Name: 2-Phenylethynesulfonamide
• Formula: C8H7NO2S
• Molecular Weight: 181.21
• Purity: >99 %
• Description: Inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Reduces cell death induced by γ -radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Product References

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma - Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma

Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova I, Bosykh DA, Burdelya LG, Macklis RM, Skaliter R, Komarova EA, Gudkov AV. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.

Linking the p53 tumour suppressor pathway to somatic cell reprogramming. - Linking the p53 tumour suppressor pathway to somatic cell reprogramming.

Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisua Belmonte JC. Nature. 2009 Aug 27;460(7259):1140-4.

A small molecule inhibitor of inducible heat shock protein 70. - A small molecule inhibitor of inducible heat shock protein 70.

Leu JI, Pimkina J, Frank A, Murphy ME, George DL. Mol Cell. 2009 Oct 9;36(1):15-27.

2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of - 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of

Steele AJ, Prentice AG, Hoffbrand AV, Yogashangary BC, Hart SM, Lowdell MW, Samuel ER, North JM, Nacheva EP, Chanalaris A, Kottaridis P, Cwynarski K, Wickremasinghe RG. Blood. 2009 Aug 6;114(6):1217-25.