Name | Piperlongumine |
---|---|
Supplier | Tocris Bioscience |
Catalog | 0763 |
Prices | $169.00, $705.00 |
Sizes | 10 mg, 50 mg |
Cas Number | 20069-09-4 |
Chemical Name | 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone |
Formula | C17H19NO5 |
Molecular Weight | 317.34 |
Purity | >97 % |
Description | Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism. |
Supplier Page | Shop |
Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Nature. 2011 Jul 13;475(7355):231-4.
Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM. Prostate. 2013 Jan;73(1):23-30.