Pitavastatin calcium

• Supplier: Tocris Bioscience
• Catalog: 4168
• Prices: $105.00, $445.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 147526-32-7
• Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoicacidhemicalciumsalt
• Formula: C25H23FNO4.0.5Ca
• Molecular Weight: 440.5
• Purity: >99 %
• Description: Synthetic inhibitor of HMG-CoA reductase (K i = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

Product References

Pharmacological profile of a novel synthetic inhibitor of - Pharmacological profile of a novel synthetic inhibitor of

Aoki T, Nishimura H, Nakagawa S, Kojima J, Suzuki H, Tamaki T, Wada Y, Yokoo N, Sato F, Kimata H, Kitahara M, Toyoda K, Sakashita M, Saito Y. Arzneimittelforschung. 1997 Aug;47(8):904-9.

Pitavastatin. - Pitavastatin.

Mukhtar RY, Reid J, Reckless JP. Int J Clin Pract. 2005 Feb;59(2):239-52.

Pitavastatin improves cardiac function and survival in association with - Pitavastatin improves cardiac function and survival in association with

Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Nishizawa T, Noda A, Izawa H, Nagata K, Murohara T, Yokota M. J Cardiovasc Pharmacol. 2006 Jun;47(6):770-9.