PJ 34 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4942
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 344458-15-7
• Chemical Name: N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride
• Formula: C17H17N3O2.HCl
• Molecular Weight: 331.8
• Purity: >98 %
• Description: Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo . Displays protective effects against cisplatin -induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC 50 values are 3.7 and 16 μ M respectively).

Product References

Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) - Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose)

Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabo C, Endres M. Int J Mol Med. 2001 Mar;7(3):255-60.

Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human - Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human

Gambi N, Tramontano F, Quesada P. Biochem Pharmacol. 2008 Jun 15;75(12):2356-63.

Identification of pim kinases as novel targets for PJ34 with confounding effects - Identification of pim kinases as novel targets for PJ34 with confounding effects

Antolin AA, Jalencas X, Yelamos J, Mestres J. ACS Chem Biol. 2012 Dec 21;7(12):1962-7.

Poly(ADP-ribose) polymerase 1 activation is required for cisplatin - Poly(ADP-ribose) polymerase 1 activation is required for cisplatin

Kim J, Long KE, Tang K, Padanilam BJ. Kidney Int. 2012 Jul;82(2):193-203.