PKC β pseudosubstrate

• Supplier: Tocris Bioscience
• Catalog: 2992
• Prices: $309.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 172308-76-8
• Formula: C177H294N62O38S3
• Molecular Weight: 3994.84
• Description: Selective cell-permeable peptide inhibitor of protein kinase C (IC 50 ~ 0.5 μ M). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Product References

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. - Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.

House C, Kemp BE. Science. 1987 Dec 18;238(4834):1726-8.

The third helix of the Antennapedia homeodomain translocates through biological - The third helix of the Antennapedia homeodomain translocates through biological

Derossi D, Joliot AH, Chassaing G, Prochiantz A. J Biol Chem. 1994 Apr 8;269(14):10444-50.

Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone - Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone

Theodore L, Derossi D, Chassaing G, Llirbat B, Kubes M, Jordan P, Chneiweiss H, Godement P, Prochiantz A. J Neurosci. 1995 Nov;15(11):7158-67.