PK-THPP

• Supplier: Tocris Bioscience
• Catalog: 4941
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 1332454-07-5
• Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
• Formula: C29H32N4O2
• Molecular Weight: 468.59
• Purity: >99 %
• Description: Potent TASK-3 channel blocker (IC 50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

Product References

Discovery of a pharmacologically active antagonist of the two-pore-domain - Discovery of a pharmacologically active antagonist of the two-pore-domain

Coburn CA, Luo Y, Cui M, Wang J, Soll R, Dong J, Hu B, Lyon MA, Santarelli VP, Kraus RL, Gregan Y, Wang Y, Fox SV, Binns J, Doran SM, Reiss DR, Tannenbaum PL, Gotter AL, Meinke PT, Renger JJ. ChemMedChem. 2012 Jan 2;7(1):123-33.

TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists - TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists

Cotten JF. Anesth Analg. 2013 Apr;116(4):810-6.