Pladienolide B

Name Pladienolide B
Supplier Tocris Bioscience
Catalog 2024
Prices $329.00
Sizes 500 µg
Function Type Inhibitor
Cas Number 445493-23-2
Chemical Name (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Formula C30H48O8
Molecular Weight 536.7
Purity >95 %
Description mRNA splicing inhibitor; decreases splicing capacity up to 75% in vitro . Directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Arrests cell cycle in G 1 and G 2/M phases. Displays antitumor activity against gastric cancer cells (IC 50 values are 1.6-4.9 nM). Cell permeable and active in vivo .
Supplier Page Shop

Product References

Identification of an encephalitogenic determinant of myelin proteolipid protein - Identification of an encephalitogenic determinant of myelin proteolipid protein

Tuohy VK, Lu Z, Sobel RA, Laursen RA, Lees MB. J Immunol. 1989 Mar 1;142(5):1523-7.

Acute experimental allergic encephalomyelitis in SJL/J mice induced by a - Acute experimental allergic encephalomyelitis in SJL/J mice induced by a

Sobel RA, Tuohy VK, Lu ZJ, Laursen RA, Lees MB. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79.

Induction of experimental allergic encephalomyelitis by myelin - Induction of experimental allergic encephalomyelitis by myelin

Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB. Pathobiology. 1991;59(5):305-12.