Plumbagin

• Supplier: Tocris Bioscience
• Catalog: 2567
• Prices: $49.00
• Sizes: 50 mg
• Cas Number: 481-42-5
• Chemical Name: 5-Hydroxy-2-methyl-1,4-naphthalenedione
• Formula: C11H8O3
• Molecular Weight: 188.18
• Purity: >98 %
• Description: Anticancer agent. Induces G 2 /M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.

Product References

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell - Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell

Hsu YL, Cho CY, Kuo PL, Huang YT, Lin CC. J Pharmacol Exp Ther. 2006 Aug;318(2):484-94. Epub 2006 Apr 21.

Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian - Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian

Kuo PL, Hsu YL, Cho CY. Mol Cancer Ther. 2006 Dec;5(12):3209-21.

Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally - Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally

Ravindra KC, Selvi BR, Arif M, Reddy BA, Thanuja GR, Agrawal S, Pradhan SK, Nagashayana N, Dasgupta D, Kundu TK. J Biol Chem. 2009 Sep 4;284(36):24453-64.

The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human - The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human

Lee JH, Yeon JH, Kim H, Roh W, Chae J, Park HO, Kim DM. PLoS One. 2012;7(9):e45023.