| Name | Pluripotin |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4761 |
| Prices | $105.00 |
| Sizes | 1 mg |
| Function Type | Inhibitor |
| Cas Number | 839707-37-8 |
| Chemical Name | N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Formula | C27H25F3N8O2 |
| Molecular Weight | 550.54 |
| Purity | >98 % |
| Description | Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF). |
| Supplier Page | Shop |
Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Scholer HR, Schultz PG, Ding S. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71. Epub 2006 Nov 6.
Mertins SD, Scudiero DA, Hollingshead MG, Divelbiss RD Jr, Alley MC, Monks A, Covell DG, Hite KM, Salomon DS, Niederhuber JE. PLoS One. 2013;8(2):e57099.