| Name | PLX 647 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4847 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Chemical Name | 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinaminedihydrochloride |
| Formula | C21H17F3N4.2HCl |
| Molecular Weight | 455.3 |
| Purity | >98 % |
| Description | Potent dual KIT/Fms inhibitor (IC 50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC 50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNF α and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo . |
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