PMPA (NAALADase inhibitor)

Name	PMPA (NAALADase inhibitor)
Supplier	Tocris Bioscience
Catalog	0627
Prices	$139.00, $579.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	173039-10-6
Chemical Name	2-(Phosphonomethyl)pentane-1,5-dioicacid
Formula	C6H11O7P
Molecular Weight	226.12
Description	Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
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Product References

Design, synthesis, and biological activity of a potent inhibitor of the - Design, synthesis, and biological activity of a potent inhibitor of the

Jackson PF, Cole DC, Slusher BS, Stetz SL, Ross LE, Donzanti BA, Trainor DA. J Med Chem. 1996 Jan 19;39(2):619-22.

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces - Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces

Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Harukuni I, Bhardwaj A, Traystman RJ, Robinson MB, Britton P, Lu XC, Tortella FC, Wozniak KM, Yudkoff M, Potter BM, Jackson PF. Nat Med. 1999 Dec;5(12):1396-402.

NAALADase inhibition protects motor neurons against chronic glutamate toxicity. - NAALADase inhibition protects motor neurons against chronic glutamate toxicity.

Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS. Eur J Pharmacol. 2003 Jun 27;471(3):177-84.

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for - Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for

Rahn KA, Watkins CC, Alt J, Rais R, Stathis M, Grishkan I, Crainiceau CM, Pomper MG, Rojas C, Pletnikov MV, Calabresi PA, Brandt J, Barker PB, Slusher BS, Kaplin AI. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20101-6. doi: