PMSF

• Supplier: Tocris Bioscience
• Catalog: 2273
• Prices: $49.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 329-98-6
• Chemical Name: Phenylmethylsulfonylfluoride
• Formula: C7H7FO2S
• Molecular Weight: 174.19
• Purity: >98 %
• Description: Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t 1/2 ~ 60 mins at pH 7.5). Brain penetrant.

Product References

The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, - The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase,

Turini P, Kurooka S, Steer M, Corbascio AN, Singer TP. J Pharmacol Exp Ther. 1969 May;167(1):98-104.

The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the - The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the

Compton DR, Martin BR. J Pharmacol Exp Ther. 1997 Dec;283(3):1138-43.

Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid - Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid

Day TA, Rakhshan F, Deutsch DG, Barker EL. Mol Pharmacol. 2001 Jun;59(6):1369-75.