PMX 464

• Supplier: Tocris Bioscience
• Catalog: 5196
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 485842-97-5
• Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
• Formula: C13H9NO2S
• Molecular Weight: 243.28
• Purity: >98 %
• Description: Putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G 1 /S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.

Product References

Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin - Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin

Mukherjee A, Westwell AD, Bradshaw TD, Stevens MF, Carmichael J, Martin SG. Br J Cancer. 2005 Jan 31;92(2):350-8.

A cellular and molecular investigation of the action of PMX464, a putative - A cellular and molecular investigation of the action of PMX464, a putative

Mukherjee A, Huber K, Evans H, Lakhani N, Martin S. Br J Pharmacol. 2007 Aug;151(8):1167-75. Epub 2007 Jun 18.

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits - PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits

Callister ME, Pinhu L, Catley MC, Westwell AD, Newton R, Leaver SK, Quinlan GJ, Evans TW, Griffiths MJ, Burke-Gaffney A. Br J Pharmacol. 2008 Nov;155(5):661-72.