PMX 53

Name PMX 53
Supplier Tocris Bioscience
Catalog 4996
Prices $235.00
Sizes 1 mg
Function Type Antagonist
Cas Number 219639-75-5
Formula C47H65N11O7
Molecular Weight 896.1
Description Potent C5a receptor antagonist (IC 50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.
Supplier Page Shop

Product References

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the - Low-molecular-weight peptidic and cyclic antagonists of the receptor for the

Finch AM, Wong AK, Paczkowski NJ, Wadi SK, Craik DJ, Fairlie DP, Taylor SM. J Med Chem. 1999 Jun 3;42(11):1965-74.

Role of complement C5a in mechanical inflammatory hypernociception: potential use - Role of complement C5a in mechanical inflammatory hypernociception: potential use

Ting E, Guerrero AT, Cunha TM, Verri WA Jr, Taylor SM, Woodruff TM, Cunha FQ, Ferreira SH. Br J Pharmacol. 2008 Mar;153(5):1043-53. Epub 2007 Dec 17.

PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in - PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in

Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H. Mol Pharmacol. 2011 Jun;79(6):1005-13.