PNU 120596

• Supplier: Tocris Bioscience
• Catalog: 2556
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 501925-31-1
• Chemical Name: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
• Formula: C13H14ClN3O4
• Molecular Weight: 311.72
• Purity: >99 %
• Description: Positive allosteric modulator of α 7 neuronal nicotinic acetylcholine receptors (EC 50 = 216 nM), with no detectable effect on α 4 β 2, α 3 β 4 and α 9 α 10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.

Product References

A novel positive allosteric modulator of the alpha7 neuronal nicotinic - A novel positive allosteric modulator of the alpha7 neuronal nicotinic

Hurst RS, Hajos M, Raggenbass M, Wall TM, Higdon NR, Lawson JA, Rutherford-Root KL, Berkenpas MB, Hoffmann WE, Piotrowski DW, Groppi VE, Allaman G, Ogier R, Bertrand S, Bertrand D, Arneric SP. J Neurosci. 2005 Apr 27;25(17):4396-405.

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing - An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing

Timmermann DB, Gronlien JH, Kohlhaas KL, Nielsen EO, Dam E, Jorgensen TD, Ahring PK, Peters D, Holst D, Christensen JK, Malysz J, Briggs CA, Gopalakrishnan M, Olsen GM. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. Epub 2007 Jul 11.

A positive allosteric modulator of alpha7 nAChRs augments neuroprotective effects - A positive allosteric modulator of alpha7 nAChRs augments neuroprotective effects

Kalappa BI, Sun F, Johnson SR, Jin K, Uteshev VV. Br J Pharmacol. 2013 Aug;169(8):1862-78.