PNU 142633

• Supplier: Tocris Bioscience
• Catalog: 2498
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 187665-65-2
• Chemical Name: (1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide
• Formula: C24H30N4O3
• Molecular Weight: 422.53
• Purity: >98 %
• Description: Very selective, high affinity 5-HT 1D receptor agonist (K i values are 6 and > 18000 nM at human 5-HT 1D and 5-HT 1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo .

Product References

Preclinical studies characterizing the anti-migraine and cardiovascular effects - Preclinical studies characterizing the anti-migraine and cardiovascular effects

McCall RB, Huff R, Chio CL, TenBrink R, Bergh CL, Ennis MD, Ghazal NB, Hoffman RL, Meisheri K, Higdon NR, Hall E. Cephalalgia. 2002 Dec;22(10):799-806.

Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator - Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator

Sanchez-Lopez A, Centurion D, Vazquez E, Arulmani U, Saxena PR, Villalon CM. Br J Pharmacol. 2003 Oct;140(4):725-35. Epub 2003 Sep 22.