PNU 282987

• Supplier: Tocris Bioscience
• Catalog: 2201
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 123464-89-1
• Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
• Formula: C14H17ClN2O
• Molecular Weight: 264.75
• Purity: >98 %
• Description: Highly selective α 7 nAChR agonist (K i = 26 nM) displaying negligible blockade of α 1 β 1 γδ and α 3 β 4 nAChRs (IC 50 ≥ 60 μ M). Found to be inactive against a panel of 32 receptors at 1 μ M, except 5-HT 3 receptors (K i = 930 nM).

Product References

Discovery and structure-activity relationship of quinuclidine benzamides as - Discovery and structure-activity relationship of quinuclidine benzamides as

Bodnar AL, Cortes-Burgos LA, Cook KK, Dinh DM, Groppi VE, Hajos M, Higdon NR, Hoffmann WE, Hurst RS, Myers JK, Rogers BN, Wall TM, Wolfe ML, Wong E. J Med Chem. 2005 Feb 24;48(4):905-8.

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 - The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987

Hajos M, Hurst RS, Hoffmann WE, Krause M, Wall TM, Higdon NR, Groppi VE. J Pharmacol Exp Ther. 2005 Mar;312(3):1213-22. Epub 2004 Nov 2.