PNU 74654

Name PNU 74654
Supplier Tocris Bioscience
Catalog 2095
Prices $139.00, $579.00
Sizes 10 mg, 50 mg
Cas Number 113906-27-7
Chemical Name 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Formula C19H16N2O3
Molecular Weight 320.34
Purity >99 %
Description Binds to β -catenin (K D = 450 nM). Inhibits the interaction between β -catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway.
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Product References

Inhibition of protein-protein interactions: the discovery of druglike - Inhibition of protein-protein interactions: the discovery of druglike

Trosset JY, Dalvit C, Knapp S, Fasolini M, Veronesi M, Mantegani S, Gianellini LM, Catana C, Sundstrom M, Stouten PF, Moll JK. Proteins. 2006 Jul 1;64(1):60-7.

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. - Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Wells JA, McClendon CL. Nature. 2007 Dec 13;450(7172):1001-9.