| Name | PNU 96415E |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3534 |
| Prices | $139.00, $579.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 170856-41-4 |
| Chemical Name | 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazinedihydrochloride |
| Formula | C21H25FN2O.2HCl |
| Molecular Weight | 413.36 |
| Purity | >98 % |
| Description | Antipsychotic agent. Displays high affinity for dopamine D 4 and serotonergic 5-HT 2A receptors and relatively weak affinity at D 2 receptors (K i values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D 4 , 5-HT 2A , 5-HT 1A , α 1 , D 2 , D 3 , D 1 , α 2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats. |
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Tang AH, Franklin SR, Himes CS, Smith MW, Tenbrink RE. J Pharmacol Exp Ther. 1997 Apr;281(1):440-7.
Goudie AJ, Smith JA, Taylor A, Taylor MA, Tricklebank MD. Behav Pharmacol. 1998 Dec;9(8):699-710.