Poly(I:C)

Name Poly(I:C)
Supplier Tocris Bioscience
Catalog 2735
Prices $89.00, $375.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 24939-03-5
Chemical Name Polyinosinic-polycytidylicacidsodiumsalt
Formula (C10H13N4O8P)x.(C9H14N3O8P)x
Description Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β -cell apoptosis. Immunostimulant.
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Product References

Nuclear factor-kappaB translocation mediates double-stranded ribonucleic - Nuclear factor-kappaB translocation mediates double-stranded ribonucleic

Robbins MA, Maksumova L, Pocock E, Chantler JK. Endocrinology. 2003 Oct;144(10):4616-25. Epub 2003 Jun 26.

Poly(I:C) used for human dendritic cell maturation preserves their ability to - Poly(I:C) used for human dendritic cell maturation preserves their ability to

Rouas R, Lewalle P, El Ouriaghli F, Nowak B, Duvillier H, Martiat P. Int Immunol. 2004 May;16(5):767-73. Epub 2004 Mar 29.

TLR signalling augments macrophage bactericidal activity through mitochondrial - TLR signalling augments macrophage bactericidal activity through mitochondrial

West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. Nature. 2011 Apr 28;472(7344):476-80.