| Name | Polygodial |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4287 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Activator |
| Cas Number | 6754-20-7 |
| Chemical Name | (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde |
| Formula | C15H22O2 |
| Molecular Weight | 234.33 |
| Purity | >97 % |
| Description | TRPA1 channel activator (EC 50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase. |
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Escalera J, von Hehn CA, Bessac BF, Sivula M, Jordt SE. J Biol Chem. 2008 Aug 29;283(35):24136-44.