POM 1

• Supplier: Tocris Bioscience
• Catalog: 3165
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 12141-67-2
• Chemical Name: Sodiummetatungstate
• Formula: H2O40Na6W12
• Molecular Weight: 2986.01
• Description: Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y 12 (K i values are 2.58, 3.26, > 10 and 28.8 μ M for NTPDase 1, NTPDase 3, P2Y 12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Product References

Polyoxometalates--a new class of potent ecto-nucleoside triphosphate - Polyoxometalates--a new class of potent ecto-nucleoside triphosphate

Muller CE, Iqbal J, Baqi Y, Zimmermann H, Rollich A, Stephan H. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. Epub 2006 Sep 25.

Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion - Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion

Grenz A, Zhang H, Hermes M, Eckle T, Klingel K, Huang DY, Muller CE, Robson SC, Osswald H, Eltzschig HK. FASEB J. 2007 Sep;21(11):2863-73. Epub 2007 Apr 18.

The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP - The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP

Wall MJ, Wigmore G, Lopatar J, Frenguelli BG, Dale N. Neuropharmacology. 2008 Dec;55(7):1251-8.