PP 1

Name PP 1
Supplier Tocris Bioscience
Catalog 3150
Prices $249.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 172889-26-8
Chemical Name 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Formula C16H19N5
Molecular Weight 281.36
Purity >99 %
Description Potent inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
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Product References

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. - Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor.

Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA. J Biol Chem. 1996 Jan 12;271(2):695-701.

Structural basis for selective inhibition of Src family kinases by PP1. - Structural basis for selective inhibition of Src family kinases by PP1.

Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM. Chem Biol. 1999 Sep;6(9):671-8.

The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. - The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.

Carlomagno F, Vitagliano D, Guida T, Napolitano M, Vecchio G, Fusco A, Gazit A, Levitzki A, Santoro M. Cancer Res. 2002 Feb 15;62(4):1077-82.

The specificities of protein kinase inhibitors: an update. - The specificities of protein kinase inhibitors: an update.

Bain J, McLauchlan H, Elliott M, Cohen P. Biochem J. 2003 Apr 1;371(Pt 1):199-204.

The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine - The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine

Tatton L, Morley GM, Chopra R, Khwaja A. J Biol Chem. 2003 Feb 14;278(7):4847-53. Epub 2002 Dec 9.