| Name | PP 121 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1397 |
| Prices | $169.00, $705.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1092788-83-4 |
| Chemical Name | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Formula | C17H17N7 |
| Molecular Weight | 319.36 |
| Purity | >99 % |
| Description | Dual inhibitor of receptor tyrosine kinases (RTKs) (IC 50 < 0.02 μ M for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC 50 < 0.06 μ M for p110 α , DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. |
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