PP 2

• Supplier: Tocris Bioscience
• Catalog: 3894
• Prices: $249.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 172889-27-9
• Chemical Name: 3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Formula: C15H16ClN5
• Molecular Weight: 301.78
• Purity: >99 %
• Description: Selective inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC 50 = 0.73 μ M). Negative control PP 3 (Cat. No. 2794) also available.

Product References

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. - Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor.

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Protein kinase inhibitors: the tyrosine-specific protein kinases. - Protein kinase inhibitors: the tyrosine-specific protein kinases.

Lawrence DS, Niu J. Pharmacol Ther. 1998 Feb;77(2):81-114.

A role for Src kinase in spontaneous epileptiform activity in the CA3 region of - A role for Src kinase in spontaneous epileptiform activity in the CA3 region of

Sanna PP, Berton F, Cammalleri M, Tallent MK, Siggins GR, Bloom FE, Francesconi W. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8653-7.

The specificities of protein kinase inhibitors: an update. - The specificities of protein kinase inhibitors: an update.

Bain J, McLauchlan H, Elliott M, Cohen P. Biochem J. 2003 Apr 1;371(Pt 1):199-204.