PPADS tetrasodium salt

• Supplier: Tocris Bioscience
• Catalog: 1923
• Prices: $75.00, $315.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 192575-19-2
• Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonicacidtetrasodiumsalt
• Formula: C14H10N3Na4O12PS2
• Molecular Weight: 599.3
• Description: A non-selective P2 purinergic antagonist. Blocks recombinant P2X 1 , P2X 2 , P2X 3 , P2X 5 (IC 50 = 1 - 2.6 μ M), native P2Y 2 -like (IC 50 ~ 0.9 mM), and recombinant P2Y 4 (IC 50 ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso -PPADS (Cat. No. 0683) also available.

Product References

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated - PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated

Lambrecht G, Friebe T, Grimm U, Windscheif U, Bungardt E, Hildebrandt C, Baumert HG, Spatz-Kumbel G, Mutschler E. Eur J Pharmacol. 1992 Jul 7;217(2-3):217-9.

Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in - Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in

McLaren GJ, Lambrecht G, Mutschler E, Baumert HG, Sneddon P, Kennedy C. Br J Pharmacol. 1994 Mar;111(3):913-7.

Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood - Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood

Ziganshin AU, Hoyle CH, Lambrecht G, Mutschler E, Bumert HG, Burnstock G. Br J Pharmacol. 1994 Mar;111(3):923-9.

Receptors for purines and pyrimidines. - Receptors for purines and pyrimidines.

Ralevic V, Burnstock G. Pharmacol Rev. 1998 Sep;50(3):413-92.

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited - Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. doi: