PPAHV

• Supplier: Tocris Bioscience
• Catalog: 0683
• Prices: $139.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 175796-50-6
• Chemical Name: [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methylesterbenzeneaceticacid
• Formula: C39H44O11
• Molecular Weight: 688.77
• Purity: >98 %
• Description: Non-pungent vanilloid TRPV1 (VR1) receptor agonist (K i = 3.1 μ M) that displays non-cooperative binding. Induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo .

Product References

A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes - A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes

Szallasi A, Acs G, Cravotto G, Blumberg PM, Lundberg JM, Appendino G. Eur J Pharmacol. 1996 Mar 28;299(1-3):221-8.

Functional and desensitizing effects of the novel synthetic vanilloid-like agent - Functional and desensitizing effects of the novel synthetic vanilloid-like agent

Griffiths CD, Vincent MA, Szallasi A, Colquhoun EQ, Geraghty DP. Br J Pharmacol. 2000 Dec;131(7):1408-12.

Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism. - Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism.

Macho A, Lucena C, Calzado MA, Blanco M, Donnay I, Appendino G, Munoz E. Chem Biol. 2000 Jul;7(7):483-92.