(±)-PPCC oxalate

• Supplier: Tocris Bioscience
• Catalog: 0620
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Cas Number: 932736-91-9
• Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylicacidmethylester
• Formula: C24H29NO3.C2H2O4
• Molecular Weight: 469.53
• Purity: >99 %
• Description: Selective sigma ( σ ) receptor ligand. Displays high affinity for σ 1 ; also binds at σ 2 sites (K i = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Product References

Novel sigma receptor ligands: synthesis and biological profile. - Novel sigma receptor ligands: synthesis and biological profile.

Prezzavento O, Campisi A, Ronsisvalle S, Li Volti G, Marrazzo A, Bramanti V, Cannavo G, Vanella L, Cagnotto A, Mennini T, Ientile R, Ronsisvalle G. J Med Chem. 2007 Mar 8;50(5):951-61. Epub 2007 Feb 13.

A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated - A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated

Prezzavento O, Parenti C, Marrazzo A, Ronsisvalle S, Vittorio F, Arico G, Scoto GM, Ronsisvalle G. Life Sci. 2008 Mar 12;82(11-12):549-53.

Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on - Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on

Antonini V, Prezzavento O, Coradazzi M, Marrazzo A, Ronsisvalle S, Arena E, Leanza G. J Neurochem. 2009 May;109(3):744-54.