PPDA

• Supplier: Tocris Bioscience
• Catalog: 3870
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 684283-16-7
• Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylicacid
• Formula: C21H18N2O5
• Molecular Weight: 378.38
• Purity: >98 %
• Description: Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (K i values are 0.096, 0.125, 0.31 and 0.55 μ M for NR2C, NR2D, NR2B and NR2A subunits respectively).

Product References

Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor - Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor

Feng B, Tse HW, Skifter DA, Morley R, Jane DE, Monaghan DT. Br J Pharmacol. 2004 Feb;141(3):508-16. Epub 2004 Jan 12.

Identification of subunit- and antagonist-specific amino acid residues in the - Identification of subunit- and antagonist-specific amino acid residues in the

Kinarsky L, Feng B, Skifter DA, Morley RM, Sherman S, Jane DE, Monaghan DT. J Pharmacol Exp Ther. 2005 Jun;313(3):1066-74. Epub 2005 Mar 2.

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid - Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid

Morley RM, Tse HW, Feng B, Miller JC, Monaghan DT, Jane DE. J Med Chem. 2005 Apr 7;48(7):2627-37.