PPPA

Name PPPA
Supplier Tocris Bioscience
Catalog 1309
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 113190-92-4
Chemical Name (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylicacid
Formula C9H18NO5P
Molecular Weight 251.22
Description Competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (K i values are 0.13, 0.47, 1.10 and 3.86 μ M for NR2A, NR2B, NR2C and NR2D subunits respectively).
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Product References

Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor - Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor

Benveniste M, Mayer ML. Mol Pharmacol. 1992 Oct;42(4):679-86.

The effect of competitive antagonist chain length on NMDA receptor subunit - The effect of competitive antagonist chain length on NMDA receptor subunit

Feng B, Morley RM, Jane DE, Monaghan DT. Neuropharmacology. 2005 Mar;48(3):354-9. Epub 2005 Jan 25.

Identification of subunit- and antagonist-specific amino acid residues in the - Identification of subunit- and antagonist-specific amino acid residues in the

Kinarsky L, Feng B, Skifter DA, Morley RM, Sherman S, Jane DE, Monaghan DT. J Pharmacol Exp Ther. 2005 Jun;313(3):1066-74. Epub 2005 Mar 2.