PPQ 102

• Supplier: Tocris Bioscience
• Catalog: 2274
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 931706-15-9
• Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
• Formula: C26H22N4O3
• Molecular Weight: 438.48
• Purity: >98 %
• Description: Potent, voltage-independent CFTR chloride channel inhibitor (IC 50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro .

Product References

Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst - Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst

Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. J Med Chem. 2009 Oct 22;52(20):6447-55.

CFTR dysfunction induces vascular endothelial growth factor synthesis in airway - CFTR dysfunction induces vascular endothelial growth factor synthesis in airway

Martin C, Coolen N, Wu Y, Thevenot G, Touqui L, Pruliere-Escabasse V, Papon JF, Coste A, Escudier E, Dusser DJ, Fajac I, Burgel PR. Eur Respir J. 2013 Dec;42(6):1553-62.