PPT

• Supplier: Tocris Bioscience
• Catalog: 4303
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 263717-53-9
• Chemical Name: 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
• Formula: C24H22N2O3
• Molecular Weight: 386.45
• Purity: >99 %
• Description: Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .

Product References

Conformational changes and coactivator recruitment by novel ligands for estrogen - Conformational changes and coactivator recruitment by novel ligands for estrogen

Kraichely DM, Sun J, Katzenellenbogen JA, Katzenellenbogen BS. Endocrinology. 2000 Oct;141(10):3534-45.

Pyrazole ligands: structure-affinity/activity relationships and estrogen - Pyrazole ligands: structure-affinity/activity relationships and estrogen

Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS, Katzenellenbogen JA. J Med Chem. 2000 Dec 28;43(26):4934-47.

Characterization of the biological roles of the estrogen receptors, ERalpha and - Characterization of the biological roles of the estrogen receptors, ERalpha and

Harris HA, Katzenellenbogen JA, Katzenellenbogen BS. Endocrinology. 2002 Nov;143(11):4172-7.