| Name | PPTN hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1426 |
| Prices | $235.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Chemical Name | 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylicacidhydrochloride |
| Formula | C29H24F3NO2.HCl |
| Molecular Weight | 511.96 |
| Purity | >98 % |
| Description | High affinity and selective P2Y 14 antagonist (K B = 434 pM). Exhibits >10,000-fold selectivity for P2Y 14 over other P2Y receptors. Inhibits UDP-glucose and MRS 2690 -induced porcine pancreatic artery contraction ex vivo . Also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro . |
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Zhou T, Parillon L, Li F, Wang Y, Keats J, Lamore S, Xu Q, Shakespeare W, Dalgarno D, Zhu X. Chem Biol Drug Des. 2007 Sep;70(3):171-81.
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