PQ 401

Name PQ 401
Supplier Tocris Bioscience
Catalog 4730
Prices $149.00, $629.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 196868-63-0
Chemical Name N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Formula C18H16ClN3O2
Molecular Weight 341.79
Purity >99 %
Description Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
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Product References

Parallel synthesis of diarylureas and their evaluation as inhibitors of - Parallel synthesis of diarylureas and their evaluation as inhibitors of

Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK. J Comb Chem. 2006 Sep-Oct;8(5):784-90.

Autocrine loop for IGF-I receptor signaling in SLUG-mediated - Autocrine loop for IGF-I receptor signaling in SLUG-mediated

Sivakumar R, Koga H, Selvendiran K, Maeyama M, Ueno T, Sata M. Int J Oncol. 2009 Feb;34(2):329-38.