PR 619

• Supplier: Tocris Bioscience
• Catalog: 1947
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 2645-32-1
• Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine
• Formula: C7H5N5S2
• Molecular Weight: 223.28
• Purity: >98 %
• Description: Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.

Product References

Activity-based chemical proteomics accelerates inhibitor development for - Activity-based chemical proteomics accelerates inhibitor development for

Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM. Chem Biol. 2011 Nov 23;18(11):1401-12.

The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the - The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the

Seiberlich V, Goldbaum O, Zhukareva V, Richter-Landsberg C. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. doi: