PRIMA-1

Name PRIMA-1
Supplier Tocris Bioscience
Catalog 5376
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Cas Number 5608-24-2
Chemical Name 2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Formula C9H15NO3
Molecular Weight 185.22
Purity >99 %
Description Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
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Product References

Restoration of the tumor suppressor function to mutant p53 by a - Restoration of the tumor suppressor function to mutant p53 by a

Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P, Bergman J, Wiman KG, Selivanova G. Nat Med. 2002 Mar;8(3):282-8.

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known - Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known

Bykov VJ, Issaeva N, Selivanova G, Wiman KG. Carcinogenesis. 2002 Dec;23(12):2011-8.

PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the - PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the

Wang T, Lee K, Rehman A, Daoud SS. Biochem Biophys Res Commun. 2007 Jan 5;352(1):203-12. Epub 2006 Nov 9.